Effect of pharmacological doses of 3-0-methyl-D-glucose and 2-deoxy-D-glucose on rat brain glucose and lactate.
نویسندگان
چکیده
منابع مشابه
Effect of pharmacological doses of 3-0-methyl-D-glucose and 2-deoxy-D-glucose on rat brain glucose and lactate.
The present investigation examined the effects of two glucose analogues, 3-0-methyl-D-glucose (30MG) and 2-deoxy-D-glucose (2DOG) on basal levels of rat brain glucose and lactate. The results showed that pretreatment (iv) with 30MG up to 2 g/kg caused a transient drop in brain glucose levels to 42% of control value within 2.5 min and a drop in lactate levels to 75% of control value by 5 min. 2D...
متن کاملThe effect of 2-deoxy-d-glucose and 3-O-methyl-d-glucose on mucosubstance secretion in cell culture.
Ouabain at lm inhibits the secretion of hyaluronic acid by Rous-sarcoma-virustransformed hamster fibroblasts in 5.5 m-glucose medium, but not in glucose-free medium (Duguid & Marsden, 1972). As the amount of secretion in glucose-free medium is 90-95 % of that in glucose-containing medium, it appears that a complex relationship exists between mucosubstance secretion, ion transport and glucose me...
متن کاملRapid, transient drop in brain glucose after intravenous phloretin or 3-0-methyl-D-glucose.
Rats were injected intravenously with either phloretin (100 mg/kg) or 3-0-methyl glucose (2 g/kg) to reduce the carrier-mediated flux of glucose into brain. Plasma glucose and brain free glucose (BFG), lactate, and glycogen were measured over a 16 min time course. Injection of these substances caused a rapid drop in BFG to 60% of control at one minute and a minimum (50% of control values) at 4 ...
متن کاملAntiangiogenic Activity of 2-Deoxy-D-Glucose
BACKGROUND During tumor angiogenesis, endothelial cells (ECs) are engaged in a number of energy consuming biological processes, such as proliferation, migration, and capillary formation. Since glucose uptake and metabolism are increased to meet this energy need, the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) on in vitro and in vivo angiogenesis were investigated. METHODOLOGY...
متن کاملThe effect of intragastric D-glucose on hyperacidity induced by histamine and carbachol in male rat
It has been shown that enhanced acid secretion can be suppressed in the rat by systemic administration of glucose. We have recently reported that enhancement of acid secretion as a result of pentagastrin was diminished by intragastric administration of D-glucose. Present study was designed to investigate whether intragastric D-glucose influences gastric acid secretion associated with carbachol ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Stroke
سال: 1986
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.17.5.957